Making their record 20th appearance in the cup decider - and sixth in the last seven years - Juve are hoping to salvage their troubled season by first lifting the Coppa and then snatching Champions League qualification from under the noses of Napoli next weekend.
Embattled coach Andrea Pirlo will prepare for the task with an almost fully available squad, though, having previously been hit by numerous defensive absences in the past two months.
However, he will be forced to reshuffle his first-choice back four a little on Wednesday, as full-back Alex Sandro picked up his second yellow card of the competition in the semi-final, so misses out through suspension.
As a result, Juan Cuadrado may be switched to right-back - despite his double strike in the Derby d'Italia last Saturday - with versatile defender Danilo moving to the left. In the centre, Leonardo Bonucci is unlikely to take start after picking up a knee sprain, so will be consigned to the bench.
Behind them, in goal, 43-year-old club legend Gianluigi Buffon has been the Bianconeri's Coppa Italia regular this term and should earn selection ahead of Wojciech Szczesny, as he hopes to put a successful full stop on his second spell at the club with a cup win.
Top scorer Cristiano Ronaldo celebrated his 100th Juventus goal last week and will lead the line as ever, but much conjecture surrounds the identity of who will join him up front in Juve's likely 4-4-2 formation.
Though Paulo Dybala was considered the man most likely to earn Pirlo's faith from the start, young Dejan Kulusevski is set to begin the game, with the Argentina forward and Alvaro Morata instead vying for playing time in the second half.
Juventus possible starting lineup: Buffon; Cuadrado, De Ligt, Chiellini, Danilo; McKennie, Bentancur, Rabiot, Chiesa; Kulusevski, Ronaldo