Both teams sealed their places at Euro 2016 and will be hoping to round into form ahead of the competition in France next year.
Italy went unbeaten in their qualifying campaign to reach Euro 2016, claiming seven wins and three draws in their 10 matches in Group H.
Antonio Conte's men were as stout as ever in their 10 matches as they conceded just seven goals, keeping four clean sheets. However, they have failed to shut out the opposition in their last three matches.
The Azzurri did have difficulty finding the net throughout their campaign as they scored 16 times in 10 matches, and they even had problems breaking down minor nations Azerbaijan and Malta in narrow victories.
Graziano Pelle has a decent record since he began his international career, netting four goals in nine appearances. However, with the competition looming Conte will be desperate for other players to step forward and strengthen his options up front.
Recent form: LWWWWL
Romania finished second behind Northern Ireland in Group F to secure their place at Euro 2016.
Anghel Iordanescu's men went through their qualifying campaign with an unbeaten record, posting five victories and five draws in their 10 matches.
Northern Ireland's performances over the course of the campaign made them sweat it out until their final match to earn their berth at the competition as they defeated the Faroe Islands 3-0 in the last round of games.
Romania built their campaign around their solid backline, which saw them concede just two goals in their 10 matches and included eight clean sheets.
Former Tottenham Hotspur defender Vlad Chiriches played an integral part in their success and will be a key player for his side ahead of the competition next year if they are to continue their success.
However, scoring goals was a major issue for Iordanescu's men as they only found the net 11 times.
Constantin Budescu and Bogdan Stancu were their team's leading marksmen with two strikes each in qualifying and their manager will hope that they can improve in the final third ahead of the tournament.
Recent form: WDDDDW
Italy possible starting lineup:
Buffon; Darmian, Bonucci, Chiellini, Antonelli; El Shaarawy, Soriano, Marchisio, Candreva; Eder, Pelle
Romania possible starting lineup:
Tatarusanu; Matel, Chiriches, Grigore, Rat; Pintilli, Hoban; Popa, Budescu, Torje; Stancu
Head To Head
The scoreline was the same in their clash at Euro 2008 after Adrian Mutu and Christian Panucci found the net within minutes of each other, but the Azzurri were grateful to a late penalty save from Gianluigi Buffon to deny Mutu a match-winning strike.
Over the course of history, Italy have dominated the fixture winning 10 of the 16 contests, while Romania have recorded just two victories. Four of the matches have ended in stalemates.
We say: Italy 0-0 Romania
Both sides struggle to score goals, but are proven to be extremely solid at the back. So, expect this match to a goalless draw as neither team looks to have the firepower to blow the other away.