Charlotte FC vs. Philadelphia (Thursday, 12.30am)
It is a match between two sides in the Eastern Conference, with the hosts sitting in 11th place before kickoff, while the visitors are up in fourth.
We say: Charlotte FC 1-1 Philadelphia Union
Charlotte FC have drawn eight out of their last 10 MLS games, including each of their last three, and they managed to hold high-flying Orlando City to a point at home at the end of August.
Considering Philadelphia Union lost 3-1 against bottom-of-the-table Toronto FC in their last away match, it would not be a surprise if the spoils are shared on Wednesday night.
How to watchYou can watch Charlotte FC vs. Philadelphia Union and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Columbus Crew vs. Chicago Fire (Thursday, 12.30am)
Wilfried Nancy's men head into the game on a run of 13 straight MLS home games without defeat against the visiting side since June 2103 and will look to continue in the same vein.
We say: Columbus Crew 3-1 Chicago Fire
Chicago Fire are in for another tough 90 minutes on Thursday as they journey to Lower.com Field, where they have failed to win their last 13 league visits since a 2-1 victory in June 2013. Nancy's side have been near impenetrable at home since the turn of the year and we see them edging out the Men in Red once again.
How to watchYou can watch Columbus Crew vs. Chicago Fire and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
DC United vs. Atlanta (Thursday, 12.30am)
Heading into the game, the hosts occupy ninth place in the table, 10 points behind the visitors, who are currently up in sixth.
We say: DC United 2-2 Atlanta United
DC United have drawn their last two matches 0-0, but they are unlikely to prevent Atlanta United from finding the back of the net, considering how impressive their opponents have been in front of goal this season.
That said, Rooney's side have looked solid since the MLS season has resumed, and we think they will be good enough to pick up a point on Wednesday.
How to watchYou can watch DC United vs. Atlanta United and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Inter Miami vs. Toronto (Thursday, 12.30am)
As we head into the final stretch of the league season, time is running out for the hosts to try and get themselves into contention for a final series playoff place while the visitors are trying to avoid a bottom-of-the-table end to the season.
We say: Inter Miami 3-1 Toronto
The hosts' main goal is to reach the playoff spots this season, and with key personnel expected to return to the squad for this match, we should see a much better display than they managed last week against Atlanta.
Toronto's away record this season has been woeful, and we feel they will suffer another defeat in this one.
How to watchYou can watch Inter Miami vs. Toronto and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Montreal vs. Cincinnati (Thursday, 12.30am)
With just six games to the end of the regular season, the Orange and Blue hold an eight-point lead at the top of the MLS table.
We say: CF Montreal 2-2 FC Cincinnati
The last five meetings between Cincinnati and Montreal have produced a combined 26 goals and we anticipate another action-packed contest at the Saputo Stadium. Noonan's men have been decent away from home in recent weeks and we predict that they will hold out for another share of the spoils.
How to watchYou can watch CF Montreal vs. FC Cincinnati and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
NY Red Bulls vs. Austin (Thursday, 12.30am)
The hosts have picked up just one point from the last 12 available while Verde and Black head into the game without a win in any of their last seven matches across all competitions.
We say: New York Red Bulls 2-1 Austin FC
New York Red Bulls and Austin have struggled to get going in recent weeks and will both head into Thursday's matchup in search of a pick-me-up. Austin's performance on the road has been nothing to write home about and we see the Red Bulls coming out on top at the Red Bull Arena.
How to watchYou can watch New York Red Bulls vs. Austin FC and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
NY City vs. Orlando City (Thursday, 12.30am)
A 0-0 draw at the Hudson River Derby versus the New York Red Bulls this past weekend kept the Pigeons four points behind the Eastern Conference playoff line, while the Lions extended their unbeaten run in league play to six matches by winning a 4-3 thriller over the Columbus Crew.
We say: New York City FC 0-2 Orlando City
Over the past couple of months, the Lions have become a well-balanced unit, adding more attacking flair to go along with their disciplined backline, and given their poise away from home and their current form, we believe they will get the job done against the Pigeons.
New York City have not played poorly throughout the campaign, but they still look indecisive in the attacking third, which might cost them again on Wednesday.
How to watchYou can watch New York City FC vs. Orlando City and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Houston vs. Vancouver (Thursday, 1.30am)
On Wednesday, a pair of sides in the mix for an MLS home playoff game will meet for the final time in the 2023 regular season as the Houston Dynamo entertain the Vancouver Whitecaps at Shell Energy Stadium.
The Dynamo were minutes away from defeating St Louis City this past weekend but ultimately had to settle for a 1-1 draw, enabling the Caps to move a point above them for fourth in the Western Conference, with Vancouver coming back to defeat Toronto 2-1.
We say: Houston Dynamo 2-1 Vancouver Whitecaps
That lopsided defeat that Orange Crush suffered versus the Caps earlier this year seems like the perfect motivation for them heading into this encounter, and when you put that together with their solid form and stingy backline at Shell Energy Stadium, it feels as though it might be too much for even a resilient Vancouver side to overcome.
How to watchYou can watch Houston Dynamo vs. Vancouver Whitecaps and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Kansas vs. Nashville (Thursday, 1.30am)
It is set to be a cross-conference match, with the hosts currently sitting 10th in the Western Conference, while the visitors are seventh in the Eastern Conference.
We say: Sporting Kansas City 2-0 Nashville SC
Although Sporting Kansas City are still outside the playoff places, they have been one of the best sides in the Western Conference over the past 20 matches, and we expect them to get the job done on Wednesday night.
Nashville SC have been in terrible form, winning just one of their last nine MLS games, and they have not won on their travels since the beginning of June, so we think it will be a relatively comfortable victory for the hosts.
How to watchYou can watch Sporting Kansas City vs. Nashville SC and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
St Louis City vs. Los Angeles (Thursday, 1.30am)
Battling for the title of the best outfit in the Western Conference, St Louis City welcome Los Angeles FC to CITYPARK on Wednesday night in MLS.
The hosts are currently three matches without a win but are still favourites to finish on top of the West, while Los Angeles are coming into this clash following a resounding success in El Trafico on the weekend.
We say: St Louis City 1-1 Los Angeles FC
St Louis have essentially secured their playoff berth which may explain a drop in form lately, but we believe they will be a stern test for the visiting LAFC on Wednesday night.
It is often difficult to replicate the energy levels after such an emotionally-draining victory against your rivals, although we feel that Cherundolo's men will be good enough for a point in this one.
How to watchYou can watch St Louis City vs. Los Angeles FC and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Colorado vs. Seattle (Thursday, 2.30am)
The away side, meanwhile, make the journey to Commerce City having had to settle for a stalemate for the second game running last time out.
Colorado Rapids snapped a five-match losing streak across all competitions by beating New England Revolution 2-1 in Sunday's encounter involving the teams.
Cole Bassett and Calvin Harris netted early in the second half to put Chris Little's men in the driving seat before Omar Gonzalez pulled one back in second-half stoppage time.
Nonetheless, the Pids remain bottom of the Western Conference of the Major League Soccer table, a whopping 14 points adrift of any form of playoff contention.
Lying in store next is the challenge of an opposing outfit who are in search of a third consecutive win in this fixture having won each of the most recent two editions by a combined score of 6-1.
Despite what has been largely an abysmal campaign to date, the home side are unbeaten in six straight games in front of their fans which makes for good reading ahead of Thursday's affair.
Seattle Sounders played out a second consecutive share of the spoils following a 1-1 draw against FC Dallas at the Toyota Stadium on Sunday.
Brian Schmetzer's men wet into the interval training at half time thanks to Jader Obrian's opener after which Alexander Roldan levelled matters.
Currently with 22 points from 27 matches to date, the Rave Greens sit third in the Western Conference standings, seven points shy of division leaders St. Louis City.
Having scored the second-most goals away from home this term, Thursday's visitors will be looking to put on another attacking masterclass on enemy territory.
We say: Colorado Rapids 1-1 Seattle Sounders
Both teams have struggled for clean sheets of late, so we are expecting goals at either end here. That said, we can see the sides cancelling each other out and settling for a point apiece in the end.
How to watchYou can watch Colorado Rapids vs. Seattle Sounders and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Salt Lake vs. Dallas (Thursday, 2.30am)
Real Salt Lake and Dallas will both be looking to secure a much-needed three points when they go head-to-head at America First Field on Thursday.
The home side have lost five of their last six games heading into this one, while the visitors are currently on a run of one win in six matches across all competitions.
We say: Real Salt Lake 2-1 Dallas
Goals have been a real feature of this fixture of late and we expect that trend to continue here. We are also backing the home side to just about get the job done at the end of the 90 minutes.
How to watchYou can watch Real Salt Lake vs. Dallas and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
LA Galaxy vs. Minnesota Utd (Thursday, 3.30am)
Like their hosts, Minnesota are also looking for a response after their seven-game unbeaten run in MLS was brought to an end by Sporting KC.
We say: Los Angeles Galaxy 1-1 Minnesota United
LA Galaxy will be determined to claim all three points to assist in their playoff bid, but we think that they will be held to a draw by Minnesota, who have avoided defeat in each of their last four MLS away matches.
How to watchYou can watch Los Angeles Galaxy vs. Minnesota United and every MLS match this season live on Apple TV. Click here for more details on how to subscribe.
Portland vs. Earthquakes (Thursday, 3.30am)
The visitors, meanwhile, will be looking to claim consecutive victories for the third time in MLS this season after beating Real Salt Lake at the weekend.
We say: Portland Timbers 2-1 San Jose Earthquakes
Portland are currently experiencing a fine run of form, and after beating San Jose on home turf in July, we think that they will draw upon that experience to claim maximum points in Wednesday's contest.