Bundesliga outfit Hoffenheim do have home advantage on their side in the second leg, albeit without fans, which they will be hoping can help carry them through into the next round.
After racing into a two-goal lead via Munas Dabbur's brace, Hoffenheim made the perfect start against Molde in what was the club's first ever European knockout match. Martin Ellingsen pulled one back for the Norwegian outfit before Christoph Baumgartner restored Sebastian Hoeness's side's two-goal cushion moments before half time.
However, Molde showed serious resolve to level the tie in the second half, with Eirik Ulland Andersen and Datro Fofana both striking within five minutes of each other to leave the tie finely balanced ahead of Thursday's second leg.
All in all, though, a high-scoring draw is never a bad result away from home in Europe. Moreover, Hoffenheim would have taken great confidence from Saturday's impressive 4-0 win against Werder Bremen, which took them up to 11th in the Bundesliga and eight points clear of the relegation zone.
Indeed, with European qualification and relegation both appearing unlikely, the Europa League may now become Hoeness's priority for the rest of the campaign. The 38-year-old must guard his players against complacency on Thursday, though, with Molde illustrating in the first leg that they are a dangerous proposition on their day.
Given that the first leg was Molde's first competitive match since the Norwegian season ended in December, their fightback against their wealthier German opponents was even more impressive.
Ellingsen's third strike in Europe this season gave Erling Moe's side hope prior to an impressive second half performance, although they certainly rode their luck at times with Hoffenheim testing goalkeeper Andreas Linde on no fewer than 13 occasions.
With the 2021 Norwegian season not beginning until early April, Moe will be hoping his side can remain in competitive European action by claiming a surprise victory in Hoffenheim on Thursday.
They will almost certainly require inspirational performances from the likes of Ellingsen and former Manchester United midfielder Magnus Wolff Eikrem in order to do so.
Hoffenheim Europa League form: WWWDWD
Hoffenheim form (all competitions): WLLDDW
Molde Europa League form: WLLWDD
Molde form (all competitions): LWWWWD
Hoffenheim remain without several first-team players, although their top goalscorer Andrej Kramaric returned sooner than expected as a substitute in the win over Bremen on Saturday and could start against Molde.
Mijat Gacinovic, Stefan Posch, Robert Skov, Havard Nordtveit, Kevin Akpoguma, Dennis Geiger, Ermin Bicakcic, Benjamin Hubner and Kostas Stafylidis are all likely to remain unavailable due to injury, though.
Molde will travel to Germany without Ola Brynhildsen, who is recovering from a fractured leg, but otherwise they appear to have a clean bill of health to choose from.
Moe is unlikely to change anything from the XI which performed admirably in Villarreal last week, although Fofana will be hoping for a start after scoring from the bench.
Hoffenheim possible starting lineup:
Baumann; Kasim, Vogt, Richards; Gacinovic, Rudy, Samassekou, John; Baumgartner; Dabbur, Kramaric
Molde possible starting lineup:
Linde; Pedersen, Bjornbak, Gregersen, Haugen; Bolly, Aursnes, Ellingsen, Andersen; Sigurdarson, Eikrem
We say: Hoffenheim 3-1 Molde (6-4 on aggregate)
We expect Hoffenheim to have learned their lessons from the first leg and keep Molde at arm's length, especially with home advantage on their side.
Whether Kramaric starts or appears from the bench, the Croatian has the ability to make a decisive difference if it proves to be required.