Stuttgart earned only their second win of the season to take all three points away at in-form Hamburg SV.
Vedad Ibisevic continued his fine recent goalscoring record, finishing neatly from close range after a sweeping Stuttgart counter.
Hamburg tried to respond through talisman Rafael van der Vaart, but he struggled to find time and space in a congested midfield.
Paul Scharner made his Hamburg debut in an advanced position late on but his efforts were in vain as Stuttgart held on for a valuable away victory.
The result is particularly sweet for under-fire Stuttgart coach Bruno Labbadia, who lasted less than a year in charge of Hamburg last season.
Hamburg missed out on the chance to go fourth and have to settle for tenth place in the Bundesliga, just a single point ahead of their conquerors Stuttgart.