While Brentford have reached this stage of the competition courtesy of wins at Southampton and West Bromwich Albion, Fulham have got the better of Ipswich Town and Sheffield Wednesday.
When Fulham earned promotion to the Premier League at the beginning of last month, Scott Parker suggested that personnel changes would be kept to a minimum.
However, on the back of three straight defeats in the top flight, co-owner Tony Khan has promised further arrivals on top of the seven new signings which have already been made in recent weeks.
The manner of the club's 3-0 defeat against Aston Villa means that it is an uncertain time for both the club and Parker, who may be concerned about the time which he will be afforded to turn things around.
Although their efforts in the Championship will not be instantly forgotten, Parker knows that survival this season is key if Fulham are to continue on an upward trajectory.
Progression in the EFL Cup is way down the list of priorities, but the Englishman will not want to give club officials any further reason to doubt whether he is the right man to take the team to the next level.
The Dane has proven people wrong by producing and continuing to develop a team which are playing some of the best football below the top flight, as well as reaping the financial benefits through player sales.
Frank has made alterations in this competition, but that has not stopped Brentford from overcoming Southampton and West Brom in recent weeks.
Despite their costly loss of form at key moments last season, the Bees do not look like faltering any time soon, and they will have full confidence that they can take another Premier League scalp regardless which players who take to the pitch on Thursday night.
Brentford EFL Cup form: DWD
Brentford form (all competitions): DLWWDD
Fulham EFL Cup form: WW
Fulham form (all competitions): LWLWL
However, goalkeeper David Raya, an alleged former target for Arsenal, is in line for his second appearance of the season.
Brentford possible starting lineup:
Raya; Dalsgaard, Goode, Sorensen, Thompson; Dasilva, Baptiste, Marcondes; Canos, Forrs, Fosu-Henry
Fulham possible starting lineup:
Rodak; Odoi, Hector, Le Marchand, Robinson; Onomah, Johansen; Knockaert, Decordova-Reid, Kebano; Kamara
We say: Brentford 3-1 Fulham
Despite the likelihood of mass changes being made, we expect Brentford's second-string to get the better of their more-proven opponents. Some of the players who feature for Fulham may be moved on before the end of the transfer window, and that may be enough for the Bees to hold the edge in this contest.