Sir Alex Ferguson has selected three strikers in his lineup for the lunchtime Premier League kickoff at Everton.
Danny Welbeck, Wayne Rooney and Javier Hernandez start for the Red Devils with the latter expected to lead the line with the two Englishmen supporting.
Nemanja Vidic and Tom Cleverley also return for United while Rio Ferdinand drops to the bench.
For the home side Louis Saha starts as a lone striker as the Toffees lineup with a five-man midfield.
Everton: T Howard; T Hibbert, P Jagielka, J Heitinga, L Baines; S Coleman, L Osman, M Fellaini, J Rodwell, D Bilyaletdinov; L Saha
Manchester United: D de Gea; P Jones, N Vidic, J Evans, P Evra; JS Park, D Fletcher, T Cleverley; D Welbeck, W Rooney, J Hernandez