The duo's inclusions are two of nine changes made by Roy Hodgson from the Three Lions' last match in Slovenia three months ago.
Rooney will become his country's all-time leading goalscorer if he scores two or more in Serravalle and reaches 50 to pass Sir Bobby Charlton's long-standing record.
San Marino: A. Simoncini; Bonini, Brolli, D. Simoncini, Berardi; Hirsch, Battistini, Chiaruzzi, M. Vitaioli; Selva
Subs: Muraccini, Benedettini, Ales. Della Valle, Alex Della Valle, Valentini, F. Vitaioli, Berretti, Golinucci, Mazza, Tosi, Rinaldi, Stefanelli
England: Hart; Clyne, Stones, Jagielka, Shaw; Milner, Shelvey, Barkley; Oxlade-Chamberlain, Rooney, Vardy
Subs: Smalling, Butland, Walcott, Cahill, Carrick, Delph, Kane, Mason, Sterling, Gibbs, Heaton
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