Frankfurt enjoyed a 3-1 victory over Hertha Berlin last time out, while Hoffenheim marched to a historic 4-1 win over champions Bayern Munich.
Having been held to a 1-1 draw by newly-promoted Arminia Bielefeld in the opening gameweek of the season, Frankfurt managed to get their campaign up and running with a comfortable win over Hertha Berlin last Friday.
Martin Hinteregger's own goal was the only dampening aspect of that victory, with Andre Silva, Bas Dost and Sebastian Rode all netting at the correct end of the pitch for Adi Hutter's men in gameweek two.
Die Adler were full value for their first victory of the season and will look to keep that momentum going as they return to familiar surroundings, where they managed to overcome Hoffenheim 1-0 last season.
However, the visitors are sure to be heading into this game with an equal or greater amount of confidence after they sent shockwaves throughout the footballing world with their performance against Bayern Munich on Sunday.
Bundesliga and Champions League winners Bayern Munich put eight past an out-of-sorts Schalke side upon their return to top-flight action, and the Hoffenheim faithful would have certainly been expecting an onslaught from the champions in gameweek two.
However, the Bavarian giants were humbled by Sebastian Hoeness's men, who ran out 4-1 winners courtesy of goals from Ermin Bicakcic, Munas Dabbur and a double from Andrej Kramaric, who now boasts five strikes from two games.
Bayern had not suffered defeat in the German top flight since December before taking on Die Kraichgauer, who currently sit top of the table at this very early stage of the campaign.
Augsburg are the only other side who have taken maximum points thus far, although Hoffenheim are now facing a Frankfurt side whom they are winless against since 2017, and Die Adler have prevailed in the last four meetings between the two clubs.
Eintracht Frankfurt Bundesliga form: DW
Eintracht Frankfurt form (all competitions): WDW
Hoffenheim Bundesliga form: WW
Hoffenheim form (all competitions): WWW
As for Hoffenheim, Hoeness will already be forced into one change from the win over Bayern, with Bicakcic being subbed off before half time after netting his side's opener.
The club have since confirmed that the Bosnian will be out for several months after tearing his ACL, so Kevin Akpoguma will likely move back into Hoffenheim's three-man defence.
Eintracht Frankfurt possible starting lineup:
Trapp; Abraham, Hasebe, Hinteregger; Toure, Ilsanker, Rode, Zuber; Kamada; Silva, Dost
Hoffenheim possible starting lineup:
Baumann; Vogt, Akpoguma, Posch; Kaderabek, Samassekou, Geiger, Skov; Baumgartner; Kramaric, Dabbur
We say: Eintracht Frankfurt 2-2 Hoffenheim
It remains to be seen whether or not Hoffenheim's memorable victory against Bayern Munich was nothing more than a fluke, but if last weekend's performance is anything to go by, Hoeness and his players ought to feel capable of beating anyone. Frankfurt have also impressed in the opening stages of the new campaign and boast a strong recent record against their opponents, so we expect the two sides to play out a high-scoring draw on Saturday.