While the Rams and Terriers occupy 18th and 19th position respectively, Rotherham United having matches in hand means that neither side can afford any complacency if they want to avoid a relegation battle.
Having witnessed Derby suffer two defeats in their last four fixtures, Wayne Rooney will recognise that his side have much work ahead if they want to avoid dropping into the third tier.
Nevertheless, collecting wins from the other two matches during that period means that the England legend can take the positives from pushing promotion contenders Watford on Friday night.
A quickfire double during the first half proved to be the difference at Vicarage Road, but Rooney will have been left impressed with how his Rams side remained in the game until the final whistle.
On the back of making multiple changes to his team, the former forward will also be satisfied that some of his players have clocked up some much-needed game time having regularly chosen a settled team.
While Derby were unable to record a surprise win against a team vying for a return to the Premier League, Huddersfield surprisingly dismantled in-form Swansea City on Saturday afternoon.
Despite facing opponents who had previously conceded just 15 goals in 28 matches, the Terriers scored four times in 55 minutes, ending the club's eight-match winless streak in emphatic fashion.
Huddersfield's home record has gone under the radar this season with Carlos Corberan's team having now prevailed in eight of their 16 fixtures at the John Smith's Stadium.
Their form on the road remains an issue, however, and you have to go back to October 31 for their last away success, when they got the better of Millwall.
Duane Holmes scored the first two goals of his second stint at Huddersfield on Saturday, a welcome boost as he prepares to face his former club.
Derby County Championship form: WWLWWL
Huddersfield Town Championship form: LDDLLW
Providing that he sticks with a 3-5-2 formation, Huddersfield boss Corberan is unlikely to make any alterations to his team.
Derby County possible starting lineup:
Marshall; Byrne, Wisdom, Clarke, Buchanan; Jozwiak, Bird, Shinnie, Waghorn; Kazim-Richards, Gregory
Huddersfield Town possible starting lineup:
Schofield; Vallejo, Keogh, Sarr; Pipa, Bacuna, Hogg, O'Brien, Rowe; Holmes, Campbell
We say: Derby County 2-1 Huddersfield Town
Ahead of such an important fixture, both teams will set out to claim what could prove to be a season-defining three points come the end of the season. While the visitors will be on a high after the weekend, we expect Derby to show their extra quality in the final third over the course of the 90 minutes.