The Rams humiliated their East Midlands rivals in the corresponding fixture last season, running out 5-0 victors to record their biggest win over Forest since 1898.
The odds on a repeat of that scoreline may not be as big as you might think, with Derby on the up and Forest very much in a prolonged rut of form.
Saturday's hosts have won four on the bounce in all competitions, all without conceding a goal, while their 1-0 victory at fellow high-flyers Ipswich Town last weekend saw them return to the automatic promotion places.
Indeed, they currently sit level on points with leaders Bournemouth, so anything other than defeat would send Steve McClaren's men top of the table for a few hours at least.
Chris Martin has been a standout performer for the Rams so far this season, and he should continue up front having notched his 100th career goal in the slender victory over Ipswich.
The Rams have only lost one league game at home all season, and they come up against a side that has won the same number of matches on the road since August.
It is now three games since Forest scored on their travels, while they have only scored three in their last seven outings both home and away.
Goals have been a major issue since Forest began their poor spell of form, and their tally of seven different goalscorers is the lowest spread in the league.
That is one of many reasons why Stuart Pearce is favourite to be the next Championship manager sacked, but the main one is a run of just two wins in their last 20 outings in all competitions.
As a result, they are now in the bottom half of the table despite being the season's early pacesetters, and actually find themselves closer to the relegation zone than they are to the playoffs.
Circumstances are certainly a lot different to when these two met at the City Ground in September, with that match ending all square.
Form in Championship: WLDWWW
Form in all competitions: LDWWWW
Possible starting lineup: Grant; Christie, Shotton, Keogh, Forsyth; Hendrick, Mascarell, Hughes; Ibe, Martin, Russell
Form in Championship: DDDLLL
Form in all competitions: DDLLLL
Possible starting lineup: Darlow; Kane, Lascelles, Mancienne, Lichaj; Tesche, Osborn, Burke, Paterson, Antonio; Assombalonga
Sports Mole says: 3-1