The former Stoke City boss failed to grab a win in his managerial debut for Palace following a 1-0 defeat to Norwich City last weekend, but two victories on the bounce can boost the club's survival hopes.
Two of their three wins this season have come on home turf, while Malky Mackay's Cardiff side have won just once on the road this season following six fixtures.
The Bluebirds began the season positively, but they have not secured a victory since their South Wales derby win over Swansea City on November 3.
For the home side, Palace could start with Cameron Jerome and Chamakh leading the line.
Crystal Palace: LLDWLW
Cardiff City: DWLDLD
Possible starting lineups
Crystal Palace: Speroni; Ward, Gabbidon, Delaney, Moxey; Jedinak, Dikgacoi, Bannan, Puncheon; Chamakh, Jerome
Cardiff City: Marshall; Theophile-Catherine, Caulker, Turner, John; Whittingham, Medel, Gunnarsson, Mutch, Cowie; Campbell
Sports Mole says: 1-1