The Reds made the fifth round of the competition last year before falling to a 2-0 defeat at home to Stoke City.
Meanwhile, Reading will be looking to make amends for last year's shock exit at the hands of Stevenage last year.
The Royals have won just two league games all season, but did beat Queens Park Rangers in the League Cup in September.
Crawley: Jones, Sadler, Connolly, McFadzean, Byrne, Akpan, Bulman, Torres, Clifford, Alexander, Elford-Alliyu
Reading: Federici, Gunter, Harte, Mariappa, Pearce, Tabb, Leigertwood, Robson-Kanu, Guthrie, Le Fondre, Hunt
Sports Mole says: 1-2