Cooper failed to shake off an ankle injury in time for the game, while Kearns was forced off during the Spireites' victory over Burton last Sunday.
Fleetwood, who are already guaranteed fourth place in the standings regardless of results today, recall striker Jon Parkin. However, Coventry loanee Adam Barton misses out on a first start for the Cod Army and must make do with a place on the bench.
Any win for Chesterfield will almost certainly give them the title, as they have a far superior goal difference to Rochdale.
Chesterfield: Lee; Talbot, Evatt, Hird, Smith; Ryan, Humphreys, Darikwa, O'Shea, Roberts; Doyle
Fleetwood Town: Maxwell, Hogan, Taylor, Schumacher, Cresswell, Jordan, Evans, Murdoch, Parkin, Blair, Morris