While Chelsea had been clear of the chasing pack in the race for fourth position, Frank Lampard's side have gone four games without success in the top flight.
Meanwhile, Spurs have recorded 10 points during the same period, putting the North Londoners back in contention for a place in next season's Champions League.
However, Jose Mourinho's side will have had under 65 hours to prepare for this contest as a result of facing RB Leipzig on Wednesday evening.
Here, Sports Mole selects a combined XI, using only the players who are expected to be available for the fixture at the weekend.
With neither Kepa Arrizabalaga nor Willy Caballero having impressed for Chelsea this season, Hugo Lloris is the logical choice between the sticks, especially after his excellent showing against Leipzig earlier this week.
Spurs teammate Serge Aurier has produced some strong performances since Mourinho's arrival, although we favour Chelsea youngster Reece James at right-back
On the opposite side, Japhet Tanganga gets the nod, with none of Jan Vertonghen, Ben Davies, Marcos Alonso or Emerson Palmieri doing enough to hold down a regular starting spot at their respective club.
When it comes to our midfield, Jorginho is selected over Eric Dier as our most defensive-minded player, and the Italian is partnered by the impressive Giovani Lo Celso, who has emerged as a star performer for Spurs since the turn of the year.
Although Dele Alli could feature up front for Spurs in Saturday's contest, the Englishman takes on his usual playmaker role in our side, aided by Willian and Steven Bergwijn on either flank.
With Tammy Abraham expected to have recovered from an ankle injury in time for Saturday's game, the Chelsea academy graduate is selected ahead of Lucas Moura.