Leicester vs. Leeds (Saturday, 12.30pm)
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Leeds United will begin life under their new head coach Jesse Marsch with a trip to the King Power Stadium on Saturday afternoon to take on Leicester City.
Marsch has taken charge of a Leeds side that currently sit down in 16th position in the Premier League table, while an inconsistent Leicester occupy 12th heading into the next set of fixtures.
We say: Leicester City 2-1 Leeds United
The Leeds players will be looking to impress their new manager this weekend, and we are expecting a much-improved performance from the visitors. Leicester were impressive against Burnley last time out, though, and we are backing the Foxes to collect all three points in front of their own supporters.
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Aston Villa vs. Southampton (Saturday, 3.00pm)
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Aston Villa will be looking to claim back-to-back Premier League victories for the first time since November when they lock horns with high-flying Southampton on Saturday afternoon.
An entertaining contest could be on the cards at Villa Park, with the Saints hoping to follow up last season's 4-3 triumph in the West Midlands with another three points.
We say: Aston Villa 2-3 Southampton
Aston Villa have recently dropped points against three teams fighting against relegation – Newcastle United, Leeds United and Watford – and while confidence will have been lifted by last weekend's win against Brighton, Gerrard's men could be in for a challenging encounter against Southampton.
Hasenhuttl's well-oiled machine has put together a strong run of form since the turn of the year and when also taking into account their impressive record against the Villans, we can see the Saints coming away with all three points on Saturday.
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Burnley vs. Chelsea (Saturday, 3.00pm)
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Chelsea will be bidding to make it three Premier League victories in a row when they travel to Turf Moor on Saturday afternoon to take on Burnley.
The Blues are currently third in the table, 16 points behind leaders Manchester City with two games in hand, while Burnley occupy 18th, one point from 17th-placed Everton ahead of this weekend's fixtures.
We say: Burnley 1-2 Chelsea
On paper, this is a very tough match for Chelsea, but the Blues have enjoyed their trips to Turf Moor in the Premier League, and we are expecting Tuchel's side to pick up another three points on Saturday afternoon.
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> How Chelsea could line up against Burnley
> Chelsea injury, suspension list vs. Burnley
Newcastle vs. Brighton (Saturday, 3.00pm)
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Seeking to extend their unbeaten Premier League run to seven games and move further away from the relegation zone, Newcastle United play host to Brighton & Hove Albion on Saturday afternoon.
The visitors, meanwhile, will be looking to avoid a fourth successive league defeat and consolidate their place in the top 10 with a victory at St James' Park.
We say: Newcastle United 1-1 Brighton & Hove Albion
There have been 22 Premier League draws in games involving Newcastle and Brighton so far this season, including the reverse fixture between the two teams, and another closely-fought contest could be on the cards this weekend.
The Seagulls will likely make themselves difficult to break down but we can see the Magpies securing at least a point on home soil to maintain their unbeaten start to 2022.
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Norwich vs. Brentford (Saturday, 3.00pm)
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Norwich City and Brentford will both endeavour to end torrid winless runs when they renew hostilities at Carrow Road for Saturday afternoon's Premier League clash.
The Canaries head into the weekend on the back of a 2-1 defeat to Liverpool in the FA Cup, while Thomas Frank's side most recently lost 2-0 to Newcastle United.
We say: Norwich City 1-2 Brentford
Brentford's inability to keep the back door shut away from home is well-documented, but Norwich boast the worst home attacking record in the division ahead of this relegation six-pointer.
Both sides will view this encounter as a priceless opportunity to end their winless runs, but with the Bees enjoying a longer period of rest and boosted by having Toney and Eriksen raring to go, we are tipping the visitors to finally post another victory as Norwich remain rooted to the bottom.
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Wolves vs. Crystal Palace (Saturday, 3.00pm)
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Wolverhampton Wanderers will be looking to move into the Premier League's top seven with a victory at home against Crystal Palace on Saturday afternoon.
The visitors, meanwhile, could sneak into the top half of the table on goal difference if they were to claim maximum points at Molineux.
We say: Wolverhampton Wanderers 1-1 Crystal Palace
Wolves have not drawn any of their last 10 Premier League matches, but they could be forced to share the spoils against a Crystal Palace side who have already drawn 12 times this season, the joint-most in the division.
A tight encounter is expected at Molineux and as both teams have been difficult to break down in recent weeks, we could see a low-scoring draw played out this weekend.
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Liverpool vs. West Ham (Saturday, 5.30pm)
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Having posted contrasting results in the FA Cup in midweek, title-chasing Liverpool and top-four challengers West Ham United prepare for battle in Saturday's Premier League showdown.
The Reds advanced to the quarter-finals of the FA Cup with a 2-1 success over Norwich City on Wednesday night, while David Moyes's men crashed out to Southampton.
We say: Liverpool 3-1 West Ham United
Liverpool may already have one eye on the second leg versus Inter, but with the majority of their big-hitters well-rested after their EFL Cup triumph, we can only envisage one result here.
West Ham have flattered to deceive on the road recently, and their first-choice XI must cope with a rapid turnaround after a disappointing midweek outing, so Klopp's men will expect to cruise to victory.
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> How Liverpool could line up against West Ham
