The Blues will go into the match with a four-point lead at the top of the table.
It will be the first time that the Portuguese manager has face the Loftus Road club.
Read what else Mourinho talked about below:
12.17pmGood afternoon! We'll be hearing from Jose Mourinho in around 15 minutes time as he prepares his side for a match against Queens Park Rangers, who have won just twice in the league this season.
12.20pmChelsea's only dropped points this season have come in matches against the Manchester sides, with City and United both holding the unbeaten side to draws. Otherwise, it's been a fairly straight-forward start to the season for Mourinho.
12.23pmThe Blues were in action in the Capital One Cup during the week, narrowly beating League Two side Shrewsbury Town 2-1. The manager had made several changes for that game, but is likely to bring the likes of Thibaut Courtois and Cesc Fabregas back into the starting XI for this match.
12.26pmMourinho could have striker Diego Costa available again after he missed last weekend's draw at Old Trafford. The manager is likely to provide updates on his other injured players as well.
12.28pmMourinho is keen today, he's arrived a few minutes early! Let's see what he has to say...
12.30pmStarting with an injury update, Mourinho confirms that Loic Remy and John Obi Mikel will both miss the match, but Ramires and Costa are both available for the game.
12.31pmOn Costa's availability, Mourinho adds: "It's good for us. It's difficult when you only have one striker available, but when you have two the situation improves."
12.33pmDidier Drogba has been featuring more in Costa's absence. When asked who decided to bring the veteran back to the club, he reveals: "Me, the owner, the board, him, we all decided together for him to come back. He had to do what no one should do - play 90 minutes of football with 48 hours difference and he managed to do that in a fabulous way."
12.35pmIt has been suggested recently that Mourinho has been unhappy with Costa's international involvement with Spain while nursing a hamstring problem. However, the manager says: "I'm always in support of players going on international duties when they are in condition to do so. I'm nobody to stand in the way of the national team, I can't stop him going away with his country."
12.36pmSticking with Costa, he adds: "He played for the national team and we lost him for four matches: Crystal Palace, Maribor, Shrewsbury and Manchester United, four matches in three different competitions. Now he is again available but he needs to be under special care."
12.39pmAttention turns to this weekend's opposition, and Mourinho tells reporters: "I think I know what to expect from QPR, and I can say it will be a difficult game for us. It's the first time I play against QPR. London is a special place because of the number of derbies, which makes it unique."
12.41pmWell, Mourinho's obviously a busy man today, because just after 10 minutes after arriving, he's done! To find out if Chelsea can maintain their unbeaten start to the season, join us from 2pm tomorrow for live coverage from Stamford Bridge. Until then, thanks for joining me today, goodbye.