The Blues are one of four sides sitting level on 10 points at the top of the rankings, whereas Nuno Espirito Santo's side dropped down to seventh following last weekend's 3-0 defeat at Crystal Palace, and here Sports Mole rounds up the team news for both sides.
Out: Japhet Tanganga (suspended)
Doubtful: Cristian Romero, Davinson Sanchez, Giovani Lo Celso (all quarantine), Son Heung-min (calf), Lucas Moura (ankle), Steven Bergwijn (ankle), Eric Dier (thigh), Ryan Sessegnon (knock)
Sports Mole's predicted XI: Lloris; Emerson, Sanchez, Romero, Reguilon; Hojbjerg, Skipp; Gil, Alli, Son; Kane
Sports Mole's predicted XI: Mendy; Azpilicueta, Christensen, Rudiger; James, Jorginho, Kovacic, Alonso; Mount, Havertz; Lukaku