The Whites, who are currently 11th in the table, will again be without the services of Adam Forshaw this weekend, while head coach Marcelo Bielsa revealed during his press conference on Thursday that Pascal Struijk and Pablo Hernandez would both be unavailable for selection.
Jamie Shackleton has been declared fit following a groin problem, though, and Rodrigo Moreno and Kalvin Phillips are both available, having come through the 2-0 defeat at West Ham United with no issues.
Robin Koch is also fit following a knee injury, but the defender will not be involved in this game, with a return for the Under-23s on Monday more likely.
Bielsa also has the option of making a change at left-back with Ezgjan Alioski pushing for a start, but Stuart Dallas is expected to once again be given the nod in what could be an unchanged back four from the defeat to West Ham at the London Stadium.
Leeds possible starting lineup: Meslier; Ayling, Llorente, Cooper, Dallas; Harrison, Klich, Phillips, Rodrigo, Raphinha; Bamford
Watch the Sports Mole Football Shorts prediction for this game below: