The champions returned to the summit of the Premier League table with a midweek win over Everton, although the destiny of the title remains out of their hands having played a game more than Liverpool.
Any slip-up against Chelsea - who have already beaten City once this season - would hand the Reds an even bigger advantage in the title race, so only a win will do for the hosts.
Here, Sports Mole looks at how Guardiola could line his side up for the contest.
Man City remain hopeful that Benjamin Mendy could be fit to return this weekend after missing the last four games due to his knee flaring up following his comeback from a lengthy injury.
The Frenchman may not be thrown straight into the starting XI for such a big game, though, particularly as Aymeric Laporte has impressed at left-back in the past two games, picking up an assist and a goal in those matches.
Bernardo Silva has established himself as one of Guardiola's most trusted players, but he played the full 90 minutes against both Arsenal and Everton and therefore may be rested for this one.