The Blues became the first team to derail City's title defence with victory in the reverse fixture in December, and a repeat of that feat this weekend would help to consolidate their place in the top four.
Maurizio Sarri's side go into the weekend sitting two points clear of Manchester United, although they could be replaced in the Champions League spots by the time they kick off on Sunday with United in action before them.
Here, Sports Mole looks at how the visitors could line up at the Etihad.
Out: Marco van Ginkel (knee)
Chelsea are blessed with a clean bill of health at the moment, and Sarri could therefore name a largely unchanged team to the one which swept Huddersfield Town aside last time out.
Antonio Rudiger will be hopeful of a recall in place of Andreas Christensen at the heart of the defence, but that may be the full extent of changes made to the XI as the Italian sticks to a winning formula.
Should that be the case then Gonzalo Higuain will be in line for another start, having opened his Chelsea account with a brace in the rout of Huddersfield, including a stunning second goal.
The likes of Mateo Kovacic, Ruben Loftus-Cheek, Callum Hudson-Odoi and Pedro are all pushing for starts, but the convincing nature of the win over Huddersfield is likely to force them to make do with a place on the bench once again.