A resounding victory over Dynamo Kiev in the last round saw Chelsea installed as favourites to go all the way and lift the Europa League trophy, and Slavia Prague are a team they will be expected to beat over two legs.
Here, Sports Mole looks at how Maurizio Sarri could line his side up for the first of those at the Sinobo Stadium.
Chelsea will be wary of complacency, but Sarri should be able to rotate his pack on Thursday and still field a team which will be favourites to put them in the driving seat for the tie.
Callum Hudson-Odoi's stock has risen to the point where he may be one of the players given a night off after consecutive Premier League starts, with Willian and Pedro both pushing for returns in the wide areas.
Olivier Giroud - who scored a hat-trick in the last round - is expected to lead the line after Gonzalo Higuain started on Monday night, while Ross Barkley, Mateo Kovacic and Andreas Christensen are among the other players who could be handed starts by Sarri.
Marcos Alonso is expected to be available to return at left-back after missing the last two games with a hamstring injury, while on the opposite flank Cesar Azpilicueta could be given a rest with Davide Zappacosta set to replace him.