The Blues have won four out of four so far in Group L, including a 1-0 win in the reverse fixture on matchday one, and are already assured of a place in the last 32 of the competition.
After slipping up in the Premier League with just three wins from their last eight matches, Chelsea boss Maurizio Sarri must now decide whether to continue with his rotation policy in Europe or prioritise a victory on Thursday night to regain some momentum.
Here, Sports Mole looks at how the Premier League giants could line up at Stamford Bridge.
Hazard was carrying an ankle injury in the 3-1 loss to Tottenham Hotspur and Ampadu, who has yet to feature under Sarri, is also nursing a knock, so both men appear certain to miss out on a place in the squad on Thursday.
The Europa League has given the likes of Cesc Fabregas and Ruben Loftus-Cheek a chance to get some minutes on the field this term, with the latter netting a hat-trick against BATE Borisov last month, and both men are expected to return to the fold this week.