The Rams go into the match in a fine spell of form having won each of their last five matches, while they have only lost once since Steve McClaren took over at the club at the end of September.
A win could move the visitors one point within the top three, although that would depend on the result in the day's early kickoff between league leaders Burnley and third-placed Leicester City.
Charlton, meanwhile, are perilously perched one place and two points above the relegation zone having picked up just four points from their last six games. Defeat could see them drop into the bottom three if Yeovil are able to beat Barnsley.
Possible starting lineups
Charlton: Alnwick; Solly, Morrison, Dervite, Wiggins; Pritchard, Cousins, Stephens, Stewart; Church, Sordell
Derby: Grant; Wisdom, Keogh, Buxton, Forsyth; Hughes, Eustace, Bryson; Dawkins, Martin, Ward
Sports Mole says: 0-2