The Addicks currently sit 15th in the table with 43 points, eight clear of the relegation zone.
"Everyone talks about 50 points but I think it will be a bit more this year because of the nature of the league," Clubcall.com quotes Powell as saying.
"It's very tight and the players know what they need to do over our last 12 games.
It's just up and down for everyone and it can be tough for supporters as well as players.
"You feel 'my team is in a good place' and then you don't win for five or six games and everyone asks 'what's going on?' Then you can win again. It's very up and down."
Charlton host Burnley in the Championship on Saturday afternoon.