The Spaniard opts to rest key players following the 4-1 win over Preston North End on Monday that sealed their return to the Premier League at the first time of asking.
Vurnon Anita, Jamaal Lascelles and Matt Ritchie had all been carrying knocks in recent weeks, playing on regardless, but have been left at home today, while Jonjo Shelvey and Aleksandar Mitrovic start the game on the bench.
Daryl Murphy returns to lead the line for the Magpies, who can cut the gap to leaders Brighton & Hove Albion to one point tonight, with Mohamed Diame back just behind him in an expected 4-4-1-1 formation.
Two changes in the back four see DeAndre Yedlin and Chancel Mbemba come in alongside Ciaran Clark and Paul Dummett, while Rob Elliot retains his place between the sticks after returning last time out following 13 months on the sidelines with a cruciate ligament injury.
For the hosts, meanwhile, Neil Warnock makes six changes to the side that were held to a goalless draw at relegation-threatened Wigan Athletic last weekend.
The five-man midfield sees only Aron Gunnarsson and Kadeem Harris retain their places, with Peter Whittingham - possibly making his final appearance in South Wales - Junior Hoilett and Greg Halford coming in for Joe Ralls, Craig Noone and Mark Harris.
Jazz Richards is preferred to Matthew Connolly alongside Sean Morrison, Bruno Ecuele Manga and Joe Bennett in the back four, while Allan McGregor is in for Ben Amos between the sticks after missing the last game with illness.
Cardiff City: McGregor; Richards, Ecuele Manga, Morrison, Bennett; Whittingham, Halford, Gunnarsson, K Harris, Hoilett; Zohore
Subs: Murphy, Peltier, Ralls, Noone, Pilkington, Connolly, Lambert
Newcastle United: Elliot; Yedlin, Mbemba, Clark, Dummett; Atsu, Hayden, Colback, Perez; Diame; Murphy
Subs: Darlow, Sterry, Haidara, Lazaar, Shelvey, Gouffran, Mitrovic
Keep up with all of the action from the Cardiff City Stadium tonight with Sports Mole's live text commentary here.