A protracted switch from former club Leyton Orient was finally completed earlier this month as Slade was officially announced as the new manager, and his first task will be to turn Cardiff's ailing fortunes around.
Ole Gunnar Solskjaer saw his time at the helm ended following a poor start to life back in the Championship, but things did not improve much in his absence.
The nadir came in their last outing as they became the first team to lose to Blackpool this season, falling to a hugely disappointing 1-0 defeat at Bloomfield Road.
That made it just one win in their last eight league outings, and Slade will have been grateful for the international break to give him a chance to mould his new side as he sees fit.
Nine of their 13 points this season have come at home, and victory over a high-flying club like Forest could act as the springboard the Bluebirds need to rise up the table.
Slade will be without Ben Turner for the match, although the defender is nearing a return from injury having missed the whole season so far.
Forest, meanwhile, go into Saturday's match in relatively poor form themselves, despite their lofty position in the league table.
Stuart Pearce's side have drawn their last four league outings yet still remain joint top with Norwich City courtesy of those around them also slipping up.
Even so, Pearce will know that four points from a possible 12 is not good enough for a side tipped by many for automatic promotion, and he will be desperate to get back to winning ways sooner rather than later.
They are, however, one of only two Championship teams who are still unbeaten this season, and their late equaliser to rescue a 2-2 draw against Ipswich Town last time out would have almost felt like a victory.
One concern for Pearce will be that the goals seem to have dried up for Britt Assombalonga, who began the season so impressively but has now gone more than a month without a goal.
Nottm Forest: DDDLDW
Possible starting lineups
Cardiff: Marshall; Connolly, Manga, S Morrison, Fabio; Pilkington, R Morrison, Gunnarson, Whittingham, Noone; Jones
Nottm Forest: Darlow; Hunt, Lascelles, Mancienne, Fox; Burke, Vaughan, Osborn, Antonio, Lansbury; Assombalonga
Sports Mole says: 1-2