Manager Carlo Ancelotti is hopeful Doucoure will return before the end of the season but will not play James until after the international break to allow the Colombia forward to fully recover from a calf problem which has restricted him to three appearances in the last eight matches.
Burnley left-back Charlie Taylor is expected to miss the match with a hamstring problem.
Taylor was replaced in last weekend's 1-1 draw with Arsenal, having initially tried to play on with the injury.
Everton provisional squad: Pickford, Holgate, Keane, Godfrey, Mina, Allan, Gomes, Sigurdsson, Davies, Calvert-Lewin, Richarlison, Olsen, Virginia, Coleman, Nkounkou, Mina, Bernard, Broadhead, King, Onyango.
Burnley provisional squad: Pope, Pieters, Lowton, Tarkowski, Mee, Cork, Taylor, McNeil, Westwood, Vydra, Peacock-Farrell, Bardsley, Long, Dunne, Brady, Berg Gudmundsson, Stephens, Driscoll-Glennon, Benson, Rodriguez, Mumbongo, Brownhill, Wood.