The Clarets, who have won eight and drew five of their 13 home fixtures, could move into second place in the Championship table if they can record a positive result against Brighton.
Garcia is expected to make several changes to the side that started against Port Vale in the FA Cup fourth round on Saturday.
Brighton & Hove Albion: WDWWLW
Possible starting lineups
Burnley: Heaton; Trippier, Lafferty, Shackell, Duff; Marney, Treacy, Jones, Barnes; Vokes, Ings
Brighton & Hove Albion: Kuszczak; Bruno, Ward, Greer, Upson; Ince, D.Lopez, Andrews, Orlandi; Ulloa, Forster-Caskey
Sports Mole says: 1-1