While the Bees are one of the form teams in the division, the Millers have claimed just one point from their last three outings in the second tier.
On the back of four draws in five matches, Brentford boss Thomas Frank was aware that his team had to find something extra in their meetings with Barnsley and Queens Park Rangers.
While the goals are still not flowing for a side who outclassed many of their opponents last season, two hard-fought victories have moved the Bees back into contention.
Although it will take more than back-to-back wins to get Brentford into the top two, the London outfit now find themselves in second place in the form table over the last half-a-dozen encounters.
That is something which will not go unnoticed by their rivals, who will also be expecting help to eventually arrive for the free-scoring Ivan Toney.
At a time when Toney has now scored 60% of Brentford's goals this season, the Bees have conceded just twice in their most recent six outings.
Despite that return from the visitors, Rotherham will be confident that they can breach Brentford's backline after their performance against Bournemouth.
A three-match winless streak means that the Millers remain down in 19th position in the table, but Warne will feel that there are reasons to be optimistic about the future.
Having previously scored just once in 10 games, Freddie Ladapo netted three goals in 94 minutes against QPR and the Cherries.
Rotherham United Championship form: LLWLLD
Brentford Championship form: WDDDWW
Rotherham boss Warne must decide whether to stick with the 3-5-2 formation which worked so effectively in their last match.
While minimal changes in personnel are expected, Dan Barlaser may be brought back into the midfield to provide some fresher legs.
With Frank frequently using different combinations in the middle of the pitch, Mathias Jensen will expect to return after only being named as a substitute last time out.
Rotherham United possible starting lineup:
Blackman; Harding, Ihiekwe, MacDonald; Olosunde, Lindsay, Wiles, Barlaser, Mattock; Smith, Ladapo
Brentford possible starting lineup:
Raya; Dalsgaard, Pinnock, Jansson, Henry; Jensen, Janelt, Marcondes; Mbuemo, Toney, Fosu-Henry
We say: Rotherham United 1-2 Brentford
On the back of their draw with Bournemouth, expect the Millers to be full of confidence. Nevertheless, an extra day of recovery for Brentford could prove key, and we are backing the visitors to show their class in a tight game.