Meanwhile, after defeat at Barnsley, the Potters head into this contest sitting four points adrift of the playoff places.
Thomas Frank would have been mightily relieved to witness his side enjoy a 3-0 win over the Owls on Wednesday night, a rare occasion where Brentford have had a comfortable 90 minutes since the turn of the year.
However, the result must mark the start of a sustained run of improvement for the Bees, whose previous three-match losing streak has left them seven points adrift of leaders Norwich City.
Swansea City's two matches in hand only ups the stakes for Brentford, and they will feel that a fixture against an inconsistent Stoke outfit provides them with an opportunity to record maximum points for the second time in three days.
Ivan Toney's quick return from injury has been welcomed by Frank, with the club's top goalscorer coming through 24 minutes without a hitch in midweek.
Nevertheless, Frank is aware that he can ill-afford any more fitness setbacks with the forward, who could prove to be the difference between automatic promotion and the playoffs.
As far as Stoke are concerned, they will be hoping for a repeat performance after recording a 3-2 win in the reverse fixture back in October.
Although that result acted as the catalyst for Brentford's prolonged unbeaten run, it did not have the same effect on Stoke, who have failed to build on a promising start to the season.
Michael O'Neill would have undoubtedly taken six points from three games against Sheffield Wednesday, Luton Town and Barnsley had it been offered to him two weeks ago.
However, the setback in the most recent of those games has led to Stoke dropping into 10th position and coming under pressure from teams directly below them.
Brentford Championship form: WWLLLW
Stoke City Championship form: DDLWWL
Toney is expected to be drafted back into the Brentford XI after his outing against Sheffield Wednesday in midweek.
Brentford possible starting lineup:
Raya; Dalsgaard, Reid, Pinnock, Sorensen; Jensen, Janelt, Dasilva; Mbeumo, Toney, Canos
Stoke City possible starting lineup:
Gunn; Smith, Souttar, Batth, Norrington-Davies; Mikel, Allen; Brown, Powell, Clarke; Vokes
We say: Brentford 3-1 Stoke City
Sensing that there is still tiredness in the Brentford ranks, O'Neill will instruct his players to make this a physical game. Nevertheless, we still expect the Bees to come through with maximum points as they bid to keep pace with their promotion rivals.