Mainz 05 vs. Union Berlin (Saturday, 2.30pm)
The visitors, on the other hand, are having a splendid second season in the German Bundesliga and will be hoping to end their recent poor run of form to move back into European qualification contention.
We say: Mainz 05 1-2 Union Berlin
Both sides will fancy their chances coming into this one, but we think the visitors should have too much quality for their struggling hosts. Union Berlin are chancing European qualification this season and should continue their charge with another three points on Saturday.
Augsburg vs. Wolfsburg (Saturday, 2.30pm)
Augsburg, meanwhile, are beginning to look nervously over their shoulders having lost four of their last five games.
We say: Augsburg 0-2 Wolfsburg
Wolfsburg have not conceded a goal in each of their last three wins, so it is tough to see Augsburg threatening the Wolves on many occasions.
It should be a comfortable afternoon for Glasner's side, with Weghorst likely to continue his hot streak in front of goal.
B. Leverkusen vs. Stuttgart (Saturday, 2.30pm)
Stuttgart, meanwhile, can move into the top half of the table with a victory.
We say: Bayer Leverkusen 1-3 Stuttgart
With Leverkusen potentially missing a whole host of first-team options, we can envisage Stuttgart blowing the hosts away.
The absence of Castro will be a blow, but the likes of Wamangituka and Nicolas Gonzalez could be too hot for Leverkusen to handle in their current crisis of confidence.
Schalke vs. RB Leipzig (Saturday, 2.30pm)
Leipzig, meanwhile, must win in order to keep their slim hopes of catching league leaders Bayern Munich alive.
We say: Schalke 04 0-2 RB Leipzig
Given that Leipzig have the tightest defence in the Bundesliga, it is difficult to envisage Schalke threatening Nagelsmann's side on too many occasions.
Leipzig should control the game almost from start to finish as they look to keep the pressure on Bayern.
Freiburg vs. Dortmund (Saturday, 2.30pm)
Freiburg, meanwhile, are looking to bounce back after last weekend's disappointingly one-sided 3-0 defeat at the hands of Wolfsburg.
We say: Freiburg 2-2 Borussia Dortmund
We can envisage an entertaining match between two sides who are in excellent offensive form but can prove leaky in defence.
Freiburg have the benefit of a much more long-serving manager at the helm, and thus a more ingrained style of play, but Dortmund have the quality individuals to make up for it.
Borussia M'bach vs. FC Koln (Saturday, 5.30pm)
Gladbach, meanwhile, can move into the Champions League qualification positions in the table with a victory.
We say: Borussia Monchengladbach 2-1 FC Koln
Koln are rarely soundly beaten, so we can see them putting up a decent fight against Gladbach.
However, the hosts should have too much offensive firepower for the relegation strugglers in the end, with Rose's side boosted by finally having a quieter schedule ahead of them.