Schalke 04 host RB Leipzig in the Bundesliga on Saturday, with the hosts needing a win to have any chance of moving off the bottom of the table.
Leipzig, meanwhile, must win in order to keep their slim hopes of catching league leaders Bayern Munich alive.
Match preview
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Schalke managed to end a run of three consecutive defeats with a 1-1 draw at Werder Bremen last weekend, but Christian Gross's side need wins on the board and fast if they are going to execute one of Europe's greatest ever escapes from relegation.
The Bundesliga's worst performing side have certainly looked a slicker outfit since Gross took charge, though, with Omar Mascarell capping off a fine team move with a nicely-placed finish from the edge of the area. Unsurprisingly, Armine Harit was at the heart of almost everything positive Schalke produced on the day, with Matthew Hoppe spurning an early chance.
However, Bremen made three substitutions at half time and improved immeasurably as a result, with two of them combining for the equaliser when Milot Rashica teed up Kevin Mohwald. Maximilian Eggestein thought he had won it with only minutes remaining, only for Theodor Gebre Selassie to be correctly adjudged to have been offside in the build-up.
Gross's hopes of delivering a trophy came to an end with a 1-0 defeat to Wolfsburg in the DFB-Pokal on Wednesday, too, but the defeat does at least allow him to fully concentrate on overseeing a miraculous survival in the league.
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Leipzig, meanwhile, comfortably overcame Bayer Leverkusen last weekend, with the 1-0 scoreline flattering the visitors on the day.
Florian Wirtz and Lucas Alario did come close to scoring on a couple of occasions, but Leipzig certainly should have had more goals themselves in a controlled performance. Marcel Sabitzer's early effort was correctly disallowed for an offside, with Christopher Nkunku smashing Julian Nagelsmann's ahead after half time with a superb first touch teeing up his accurate strike into the top corner.
Alexander Sorloth later struck the post, with Dani Olmo narrowly missing the rebound, but Leipzig held on for a win which just about keeps them in the hunt for their first ever Bundesliga title.
A more likely trophy for them this season may well be the DFB-Pokal, with Wednesday's 4-0 win over VfL Bochum taking Leipzig into the quarter-final. After losing 3-0 to Bayern in the 2019 final, Nagelsmann would surely revel in delivering Leipzig's first ever major trophy to the club.
Schalke 04 Bundesliga form: LWLLLD
Schalke 04 form (all competitions): WLLLDL
RB Leipzig Bundesliga form: WLDWLW
RB Leipzig form (all competitions): LDWLWW
Team News
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Schalke are still missing a whole host of players through injury, with Can Bozdogan, Suat Serdar, Frederik Ronnow, Steven Skrzybski, Kilian Ludewig, Salif Sane and Goncalo Pacienca all unavailable.
Nabil Bentaleb is still effectively persona non grata at the club after his disciplinary issues in November, with Shkodran Mustafi perhaps having to wait for his first start having joined from Arsenal on transfer deadline day.
Leipzig, meanwhile, will travel to Schalke without Kevin Kampl, Dominik Szoboszlai, Emil Forsberg, Ibrahima Konate, Benjamin Henrichs and Konrad Laimer due to injury.
Nagelsmann is likely to shuffle the pack once more, with Yussuf Poulsen pushing for a start after his brace in the cup in midweek.
Schalke 04 possible starting lineup:
Fahrmann; Becker, Thiaw, Nastasic, Kolasinac; Mascarell, Stambouli; Schopf, Uth, Harit; Hoppe
RB Leipzig possible starting lineup:
Gulasci; Mukiele, Upamecano, Halstenberg; Adams, Sabitzer, Haidara, Angelino; Olmo, Nkunku; Sorloth
We say: Schalke 04 0-2 RB Leipzig
Given that Leipzig have the tightest defence in the Bundesliga, it is difficult to envisage Schalke threatening Nagelsmann's side on too many occasions.
Leipzig should control the game almost from start to finish as they look to keep the pressure on Bayern.
Top betting tip
Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a RB Leipzig win with a probability of 71.65%. A draw had a probability of 16.6% and a win for Schalke 04 had a probability of 11.73%.
The most likely scoreline for a RB Leipzig win was 0-2 with a probability of 10.56%. The next most likely scorelines for that outcome were 1-2 (9.46%) and 0-3 (8.66%). The likeliest drawn scoreline was 1-1 (7.7%), while for a Schalke 04 win it was 2-1 (3.45%). The actual scoreline of 0-3 was predicted with an 8.7% likelihood. Our data analysis correctly predicted that RB Leipzig would win this match.