The 28-year-old is expected to be out until early next year after tearing his cruciate ligament as Dortmund beat Eintracht Frankfurt 2-1 in the German Cup final in May.
Previously, Reus missed Germany's World Cup-winning campaign in 2014 with torn ankle ligaments, and suffered a groin injury which ruled him out of Euro 2016, before sustaining a heel problem in November and a torn hamstring in March.
Reus has now revealed the emotional impact of his latest injury and admits that he just wants to get back to playing football regularly.
"The tears came again two or three days later when I went through it again in my mind," Reus told GQ when asked about the injury he sustained in May's cup final win.
"To be alone, working your way back is the most demanding part. I was really fed up after three weeks. It's a brutal mental test because you always have to work on your own.
"As top players, we earn a lot of money, but sometimes we pay a hefty price with our health. I would give away all the money to be healthy again, to be able to do my job. To do what I love - to play football."
Reus joined Dortmund from Borussia Monchengladbach in 2012 and has made 189 appearances for the North Rhine-Westphalia club to date.