The hosts have lost four of their last six games after their impressive start to the season, but could go into the playoff positions with a win.
Brighton & Hove Albion haven't won in their last five matches and have suffered recent back-to-back defeats to high-flyers Middlesbrough and Leicester City.
A win for the Seagulls could move them also in the top six.
Possible starting lineups:
Blackpool: Gilks; Eardley, Cathcart, Baptiste, Evatt; Crainey, Angel, Osbourne; Phillips, Taylor-Fletcher, Ince
Brighton: Kuszczak; Bruno, Greer, El-Abd, Bridge; Hammond, Crofts, Lopez, Bridcutt; Mackail-Smith, Barnes
Sports Mole says: 2-1