They have the fourth-best away record in the Championship, having taken 19 points from 12 games on the road.
The Uruguayan will have a full compliment of players to choose from and is unlikely to make many changes to the side that beat Derby County 2-1 at the Amex Stadium.
Another yellow card for midfielder Dean Hammond will see him get a one-match ban.
The Blues are struggling at the foot of the table, with just five points separating them from 22nd-placed Peterborough United.
Jack Butland should return between the sticks after sitting out Tuesday's 2-1 home defeat to Leeds United in the FA Cup.
Birmingham: Butland; Davies, Pablo, Robinson, Caldwell; Burke, Lovenkrands, Redmond; Elliott, Zigic
Brighton: Kuszczak; Greer, El-Abd, Calderon, Bridge; Hammond, Orlandi, Bridcutt, Buckley; Barnes, Lopez,
Sports Mole says: 1-2