The Seville-based outfit will enter the match off the back of a 1-0 win over Espanyol, while Levante saw a four-game unbeaten run in the league ended by Atletico Madrid on Tuesday night.
Levante have finished 15th in La Liga in each of their last two seasons, while they have not ended a top-flight campaign in a position higher than 14th since 2013-14.
Granotas are only four points off the top of the table, meanwhile, and will be eyeing their 12th league victory of the season when they welcome Betis to Valencia.
Levante had picked up four points from two matches against Sevilla and Espanyol before Tuesday's clash with Atletico, but Lopez's side suffered a 1-0 defeat to the capital giants on home soil.
Betis, meanwhile, will enter this weekend's match off the back of a 1-0 victory over Espanyol on Thursday night, where Marc Bartra scored the only goal of the contest early in the second period.
The Seville-based side had gone three games without a victory ahead of the clash with the Catalan outfit, losing to Sevilla and Athletic Bilbao since resuming their campaign on June 11.
Nine wins, 10 draws and 12 defeats - that is how Los Verdiblancos have performed this season, with a total of 37 points from 31 matches leaving them in 13th position in the table.
Betis are under new management for the latter stages of the campaign, meanwhile, with Alexis Trujillo recently replacing Rubi on an interim basis; it is actually the second time that Trujillo has acted as interim boss, having also held the position for two games towards the end of the 2017-18 campaign.
Levante La Liga form: LDDDWL
Betis La Liga form: LWLDLW
Levante will be without the services of Nikola Vukcevic through suspension due to the yellow card that the midfielder picked up in the 1-0 loss to Atletico last time out.
William Carvalho and Carles Alena were both on the bench last time out but could feature in the starting XI, although Borja Iglesias is again expected to get the nod over Loren Moron in the final third of the field.
Levante possible starting lineup:
Aitor; Coke, Vezo, Postigo, Tono; Rocinha, Campana, Radoja, Bardhi; Morales, Mayoral
Real Betis possible starting lineup:
Joel; Mandi, Bartra, Feddal; Emerson, Alena, Carvalho, Pedraza; Fekir, Iglesias, Tello
We say: Levante 1-1 Real Betis
Betis will have been boosted by their victory over Espanyol, and there is no question that the Green and Whites have a lot of talented players. They have only recorded one away league victory this season, though, while Levante have suffered just four defeats on their own patch; we fancy a low-scoring draw.