The sides meet at the BayArena in their Group A match, with Shakhtar sitting one point ahead of Leverkusen after their first two fixtures.
Hyypia admits that their opponents are a threat going forward but he is confident that his team can show their own qualities in what will be a crucial match for the Germans.
"Shakhtar have five, six players from South America. I think they are better when they attack and have problems when they have to defend. Their style is always the same - at home or away," UEFA quotes him as saying on their official website.
"We have to be well prepared and try to benefit from their offensive play so that we have more attacking players than they have defenders and we will get chances to score hopefully. But at least we were nervous with the ball sometime, especially in Manchester.
"Little things will be essential. We have to move more, pass the ball with better quality and have to concentrate, then we're able to show our good skills."
Leverkusen are currently third in the Bundesliga table.