Their hopes of winning the Champions League may be hanging by a thread following Wednesday's 2-0 defeat to AC Milan, but Barcelona are clear favourites to regain the La Liga title from Real Madrid this season.
Barca have been made the clear favourites to win this encounter, thanks largely to Sevilla's record away from home this season. They have won just once on the road, drawing four times and losing seven other matches.
Last season they left the Camp Nou with a 0-0 draw, but in the three encounters prior to that, Barca scored 13 goals without reply.
Following the loss to Milan, Barca may make a couple of changes to their lineup for the visit of Sevilla. That could mean a recall for Alexis Sanchez and Thiago, but David Villa is unlikely to feature following a recent hospital visit with kidney stones.
Possible starting lineups
Barcelona: Valdes; Alves, Pique, Puyol, Alba; Xavi, Iniesta, Thiago; Pedro, Sanchez; Messi
Sevilla Beto; Spahic, Fazio, Coke, Alberto Moreno; Reyes, Navas, Rakitic, Medel, Kondogbia; Negredo
Sports Mole says: 2-1