The Catalan giants kicked off a new era under Ronald Koeman in style on Sunday with a routine 4-0 victory over Villarreal.
However, the visitors have failed to win any of their last five league meetings at Balaidos, losing three of those recent encounters.
Ahead of this latest tussle in Galicia, Sports Mole looks at how Barca could line up.
First-choice goalkeeper Marc-Andre ter Stegen and back-up forward Martin Braithwaite have been ruled out of this game with knee and thigh injuries respectively.
Samuel Umtiti is also unlikely to play any part due to an ongoing knee issue, which has kept him out of the squad since June.
Lionel Messi, on target from the penalty spot on Sunday, will almost certainly lead the line as he looks to build on a return of 11 goals in 16 La Liga appearances against Celta.