Mascherano received criticism from the Catalan press for his performance against Real Madrid in the Super Cup Final, which Barca lost over two legs.
He told Mundo Deportivo: "I run a lot more risk playing centrally for Barca than in any other team due to how we play.
"We are constantly attacking and yes, we have 70% of possession, but three or four times they will attack you.
"Every mistake, like mine against Real Madrid, is a goal. Playing in the centre at Barcelona is a risk, but I also particularly like to run that risk."
Mascherano was talking to the media ahead of Argentina's World Cup qualifier against Peru on Tuesday.