The Argentine is still not 100% fit to feature for the Catalan outfit following his exploits at the World Cup, but Enrique has insisted that the former Ballon d'Or winner is his main man for the new campaign.
"Leo has so many options that we can't close off any to him," he told reporters.
"He will have total freedom to move in attacking situations. He is the best in the world, without a doubt, and we adapt to his mobility."
Barcelona open their La Liga challenge against Elche next weekend.