There was initial hope that Neymar would recover from a groin problem in time to face his old club, but the Brazilian attacker is yet to fully overcome a groin problem and he will play no part in the second leg.
As a result, hat-trick hero Kylian Mbappe is expected to occupy the left-wing spot as he bids to become the youngest player ever to score 25 goals in the Champions League, while the returning Angel Di Maria could demote Pablo Sarabia down to the bench, despite the Spaniard's good run of form recently.
With Kean sidelined, Pochettino will likely call upon his compatriot Mauro Icardi to lead the line after he was benched against Brest, while Marco Verratti is set to occupy the number 10 role ahead of Julian Draxler and Rafinha.
Idrissa Gueye and Leandro Paredes should act as Pochettino's double pivot, and there will be a raft of changes in defence, as potentially all five members of the rearguard from the weekend's Coupe de France win could drop out.
Keylor Navas will certainly come back in goal for Sergio Rico, while Mitchell Bakker, Abdou Diallo and Danilo Pereira will make way for Layvin Kurzawa, Marquinhos and Presnel Kimpembe, and Alessandro Florenzi should overcome a muscle complaint in time to start as well.
Paris Saint-Germain possible starting lineup:
Navas; Florenzi, Marquinhos, Kimpembe, Kurzawa; Gueye, Paredes; Di Maria, Verratti, Mbappe; Icardi