Diego Simeone's side have picked up five points from their first three league games of the season to sit 12th in the table, while Celta occupy 13th with five points to show from their five outings this term.
Celta started their 2020-21 La Liga season with a point at Eibar on September 12 before recording an impressive 2-1 home victory over Valencia one week later to put four points on the board.
Another point arrived away to Real Valladolid on September 27, but Celta have lost their last two in Spain's top flight, suffering a 3-0 defeat at home to Barcelona before going down 2-0 at Osasuna last time out.
A return of five points from five matches represents a solid start to the campaign and as mentioned, Oscar Garcia's side are currently 13th in the division, level on points with Atletico.
The Sky Blues have only just survived in La Liga in each of the last two seasons - finishing 17th on both occasions - and it does appear that they will again be reliant on Iago Aspas for goals this term.
Atletico, meanwhile, only started their league season at the end of September due to their involvement in the knockout stages of the 2019-20 Champions League.
Simeone's side opened their campaign with a thumping 6-1 win over Granada at the Wanda Metropolitano, but they have drawn their last two matches, both 0-0, with Huesca and Villarreal.
Atletico will be determined to put three points on the board this weekend and will again be looking to Luis Suarez for goals, with the summer arrival from Barcelona already netting twice for the capital outfit.
The Red and Whites also have the small matter of a trip to Bayern Munich in the Champions League on Wednesday, which is shaping up to be a fascinating contest at the Allianz Arena.
Atletico will enter Saturday's clash as the favourites, but they have only won one of their last four La Liga games with Celta and have not been victorious in Vigo since October 2017.
Celta Vigo La Liga form: DWDLL
Atletico Madrid La Liga form: WDD
Kieran Trippier should also be available despite being forced to pull out of the England squad ahead of Wednesday's UEFA Nations League clash with Denmark to attend a personal FA hearing.
Celta Vigo possible starting lineup:
Villar; Araujo, Aidoo, Murillo, Olaza; Tapia, Beltran; Nolito, Mor, Denis Suarez; Aspas
Atletico Madrid possible starting lineup:
Oblak; Trippier, Savic, Felipe, Hermoso; Correa, Koke, Llorente, Carrasco; Luis Suarez, Felix
We say: Celta Vigo 0-1 Atletico Madrid
Simeone will be desperate for his side to return to winning ways after back-to-back draws, and we just fancy the visitors to triumph on Saturday afternoon. Celta are certainly capable of causing issues, but Atletico should have enough to record their second league win of the season.