PSG have already claimed all three domestic honours on offer and are now looking to triumph on the continental stage for the first time, with this Atalanta's debut at this stage.
The one-legged match will be played at the Estadio da Luz after the remainder of UEFA's showpiece competition was switched to Lisbon in the wake of the coronavirus pandemic.
As incredible as it may sound on the face of it, 2019-20 could yet be deemed a disappointment for PSG despite the fact that they have those three trophies in the bag.
They were crowned French champions in March after the coronavirus pandemic ended the Ligue 1 season 11 games early, boasting a 12-point lead at the summit at the time.
PSG then had a five-month wait before beating Saint-Etienne 1-0 in the Coupe de France final on July 24, a week before overcoming Lyon on penalties in the Coupe de la Ligue final.
Thomas Tuchel's men have also played a number of friendlies to keep them ticking over and, taking those fixtures into account, have scored 17 goals since last conceding.
Scoring goals is not exactly an issue for the French giants, either, even if Kylian Mbappe is a major doubt for this clash with Atalanta due to an ankle injury.
That is especially true on the continent, having scored in each of their last 32 Champions League games since the 2015-16 season - the longest current streak in the competition.
Goals can very much be expected in Lisbon on Wednesday as Atalanta scored an incredible 98 times in Serie A en route to finishing third this season.
That is a tally that only Manchester City (102) and Bayern Munich (100) can better in Europe's top five leagues.
Atalanta have conceded more goals than any other remaining team in this season's Champions League, however, and have the highest expected goals against tally among the final eight.
While PSG will arguably enter this match a little rusty, even accounting for those two recent finals, Atalanta will be near enough at peak fitness.
The Italian side have played 13 times in the last five months, winning nine of those matches and losing just one.
Like their opponents, though, La Dea are without their leading marksman as Josip Ilicic has missed the last month because of personal reasons.
Atalanta BC Champions League form: LDWWWW
Atalanta BC form (all competitions): WDWDWL
Paris Saint-Germain Champions League form: WWDWLW
Paris Saint-Germain form (all competitions): WWWWWW
That could force Tuchel into a tactical rethink, with his favoured 4-4-2 formation likely to become a 4-3-3.
Atalanta BC possible starting lineup:
Sportiello; Toloi, Caldara, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Gomez, Malinovskiy; Zapata
Paris Saint-Germain possible starting lineup:
Navas; Kehrer, Silva, Kimpembe, Bernat; Gueye, Marquinhos, Herrera; Sarabia, Icardi, Neymar
We say: Atalanta BC 1-3 Paris Saint-Germain
PSG have not reached the semi-final stage of the Champions League since 1994-95, while Atalanta had never previously made it this far. The Ligue 1 champions have not won a single game against Italian opposition in the competition in six attempts, but we can see them ending that hoodoo in Wednesday's encounter.