Villa are boosted by the starting return of Ahmed Elmohamady at right-back following a recent injury, while Robert Snodgrass, Albert Adomah and Jack Grealish will provide creative support for lone frontman Lewis Grabban.
Fulham boss Slavisa Jokanovic has caused no real surprises with his starting XI, leaving Aleksandar Mitrovic to start up top, while the striker will be assisted by Ryan Sessegnon and Aboubakar Kamara on the flanks.
Aston Villa: Johnstone; Elmohamady, Chester, Terry, Hutton; Jedinak, Hourihane; Snodgrass, Adomah, Grealish; Grabban
Subs: Bunn, Bree, Whelan, Bjarnason, Onomah, Hogan, Kodjia
Fulham: Bettinelli; Fredericks, Odoi, Ream, Targett; McDonald, Cairney, Johansen; Kamara, Sessegnon, Mitrovic
Subs: Button, Kalas, Christie, Norwood, Ayite, Piazon, Fonte