However, Arteta will take encouragement from the North London outfit having avoided defeat in their last two outings, both of which have been played away from the Emirates Stadium.
Here, Sports Mole predicts how Arsenal could line up for the clash with one of their fiercest rivals.
Out: Kieran Tierney (shoulder), Sead Kolasinac (ankle),
Doubtful: Hector Bellerin (hamstring), Gabriel Martinelli (thigh), Dani Ceballos (hamstring), Rob Holding (knee), Sokratis Papastathopoulos (head)
Despite the 1-1 draw at the Vitality Stadium, Arteta is likely to freshen up his team for the visit of Frank Lampard's side.
Having sustained a head injury against the Cherries, Sokratis Papastathopoulos may be replaced by Calum Chambers, who missed the last match through suspension.
However, Mesut Ozil's participation from the opening whistle could potentially depend on if Dani Ceballos has shaken off a hamstring injury, which has kept him sidelined for a number of weeks.
Providing that he has recovered from a minor thigh issue, Gabriel Martinelli may return, although Nicolas Pepe will be hopeful of a recall.