The Blues have won just one of their last seven matches at home, with their latest outing seeing them squander a two-goal lead to eventually draw 2-2 with Southampton.
Arsenal, meanwhile, have yet to pick up a league win in 2013, but did seal their place in the FA Cup fourth round with a 1-0 win over Swansea in their last match.
The London rivals sit third and sixth respectively in the Premier League table, and a win for the Gunners could see them displace Everton in fifth.
The reverse fixture between these two sides earlier in the season finished 2-1 to Chelsea at the Emirates Stadium.
Chelsea: Cech; Azpilicueta, Cahill, Ivanovic, Cole; Luiz, Lampard; Mata, Hazard, Oscar; Ba
Arsenal: Szczesny; Sagna, Koscielny, Mertesacker, Gibbs; Wilshere, Diaby, Oxlade-Chamberlain, Cazorla, Podolski; Walcott
Sports Mole says: 3-2