The Gunners have been largely inconsistent so far in their league campaign and the club will be hoping to recover from their 3-3 draw with Fulham last weekend, in which they had the chance to take maximum points when Mikel Arteta stepped up to take a last-minute penalty but the shot was saved.
Meanwhile, Spurs have lost their last two league fixtures and they will be determined not to record a third when they travel to the Emirates on Saturday lunchtime.
Wenger could welcome back midfielder Jack Wilshere to the side, who has served a one-match suspension after getting sent off against Manchester United a fortnight ago.
Arsenal: Mannone; Sagna, Koscielny, Mertesacker, Vermaelen; Wilshere, Arteta, Cazorla; Walcott, Giroud, Podolski
Tottenham: Friedel; Walker, Gallas, Caulker, Vertonghen; Sandro, Huddlestone; Lennon, Bale, Dempsey; Adebayor
Sports Mole says: 2-1