Arsenal have ventured on a winning streak as well, having commenced the campaign with a 3-1 home defeat to Aston Villa. A 3-1 win at Fulham and successive victories over Fenerbahce in the Champions League playoff round mean that Arsene Wenger's men will head into the North London derby with confidence.
Arsenal will have Laurent Koscielny back in contention following his one-match domestic suspension, while Mathieu Flamini is likely to be drafted back into the squad.
Aaron Ramsey has recovered from his groin injury and will start for the Gunners, but Lukas Podolski is out for three months with a torn hamstring.
Meanwhile, Spurs will be without winger Gareth Bale, who is expected to join Real Madrid in the coming days. Roberto Soldado will retain his place in the starting lineup.